ALDOC- AND ENO2- DRIVEN GLUCOSE METABOLISM SUSTAINS 3D TUMOR SPHEROIDS GROWTH REGARDLESS OF NUTRIENT ENVIRONMENTAL CONDITIONS: A MULTI-OMICS ANALYSIS

Abstract Background Metastases are the major cause of cancer-related morbidity and mortality.By the time cancer cells detach from their primary site to eventually spread to distant sites, they need to acquire the ability to survive in non-adherent conditions and to proliferate within a new microenvironment in spite of stressing conditions that may